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Abstract #2282

Simple Method for Off-Resonance Gas Artifact Removal in 129Xe Gas-Transfer MRI

Matthew Willmering1, Peter Niedbalski1, Laura Walkup1,2, Zackary Cleveland1,2, and Jason Woods1,2
1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2University of Cincinnati, Cincinnati, OH, United States

Hyperpolarized dissolved-phase 129Xe imaging allows pulmonary gas transfer processes to be quantified at multiple stages and physical abnormalities in gas-exchange to be identified in subjects with pulmonary disease. However, the technique is hindered by gas-phase contamination due to imperfect frequency-selective excitation of the 50-fold larger pool of gaseous 129Xe. The previous method to remove this contamination required additional echoes. We present a simple post-acquisition method to remove gas-phase contamination with >90% efficiency. This method can be applied to the standard gas-transfer MRI sequence, thus permitting contamination removal for existing data, facilitating more accurate and consistent hyperpolarized 129Xe gas-transfer imaging.

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