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Abstract #2283

Noninvasive Diagnosis of Pulmonary Hypertension with Hyperpolarized 129Xe Magnetic Resonance Imaging and Spectroscopy

Elianna Ada Bier1, Ziyi Wang1, Hamid Chalian2, Joseph Mammarappallil2, John C Nouls2, Leith Rankine3, Junlan Lu3, Bastiaan Driehuys2, and Sudarshan Rajagopal4
1Biomedical Engineering, Duke University, Durham, NC, United States, 2Radiology, Duke University Medical Center, Durham, NC, United States, 3Medical Physics Graduate Program, Duke University, Durham, NC, United States, 4Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, United States

Using unique signatures in 129Xe MR 3D gas exchange imaging and dynamic spectroscopy, we tested an algorithm to detect pulmonary hypertension (PH). The algorithm was developed using a training cohort (n=105) and tested on 25 subjects whose PH status was determined via right heart catheterization. Two expert readers rated scan quality and interpreted each subject’s 129Xe MRI/MRS to determine PH status. Using the 16 patients for which readers rated scan diagnostic quality as 4-5/5, the diagnostic accuracy was 0.84 (sensitivity=0.78, specificity=0.93). This model demonstrates the ability to distinguish subjects with pre-capillary PH from those without PH or with post-capillary PH.

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