Meeting Banner
Abstract #2285

Regional hyperpolarised 129-xenon MR spectroscopy and diffusion-weighted MRI in patients with idiopathic pulmonary fibrosis

James A Eaden1,2, Ho-Fung Chan1, Guilhem J Collier1, Nicholas D Weatherley1, Jim Lithgow1, Oliver Rodgers1, Jody FD Bray1, Graham Norquay1, Stephen M Bianchi2, and Jim M Wild1,3
1POLARIS, MRI unit, Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 2Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 3Insigneo institute, University of Sheffield, Sheffield, United Kingdom

Preliminary findings are presented from a prospective, longitudinal hyperpolarised 129Xe MRI study of idiopathic pulmonary fibrosis patients. To date, 28 patients have undergone baseline 129Xe DW-MRI and 10 patients have returned for a six-month scan. 14 patients have undergone baseline dissolved 129Xe imaging using IDEAL CSI method. Regional values were produced by separating the lung into three zones. We demonstrate regional differences in 129Xe gas transfer and 129Xe DW-MRI measurements. LmD was found to be more sensitive to longitudinal change than ADC. Over a six-month period, the significant change in mean 129Xe LmD was observed in the lower zone only.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords