Imaging of the different resonances of dissolved hyperpolarized xenon in the lung is performed using a 4-echo flyback 3D radial implementation of the IDEAL technique and is evaluated in subjects with idiopathic pulmonary fibrosis. Results show:
- excellent chemical shift separation of the dissolved peaks and gas contamination removal,
- agreement with global spectroscopic and pulmonary function measurements of gas transfer,
- reduced imaging gas transfer, especially in the basal lung, when compared to healthy volunteers,
- increased cardiogenic modulation of dissolved xenon signal in the blood.
Clinical results are in line with previously-published data.