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Abstract #2286

Dissolved 129Xe lung MRI with 4-echo IDEAL 3D radial CSI: quantification of regional gas transfer in idiopathic pulmonary fibrosis

Guilhem Jean Collier1, James A Eaden1, Paul J Hughes1, Stephen M Bianchi2, Neil J Stewart1, Nick D Weatherley1, Graham Norquay1, Rolf F Schulte3, and Jim M Wild1
1Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 2Academic directorate of respiratory medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 3GE Healthcare, Munich, Germany

Imaging of the different resonances of dissolved hyperpolarized xenon in the lung is performed using a 4-echo flyback 3D radial implementation of the IDEAL technique and is evaluated in subjects with idiopathic pulmonary fibrosis. Results show:

- excellent chemical shift separation of the dissolved peaks and gas contamination removal,

- agreement with global spectroscopic and pulmonary function measurements of gas transfer,

- reduced imaging gas transfer, especially in the basal lung, when compared to healthy volunteers,

- increased cardiogenic modulation of dissolved xenon signal in the blood.

Clinical results are in line with previously-published data.

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