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Abstract #2288

Assessment of Gas Exchange for Lung Volume Reduction Surgery in an Emphysema Rat Model Using Xenon Polarization Transfer Contrast Imaging

Faraz Amzajerdian 1,2, Luis Loza1, Tahmina Achekzai1, Federico Sertic1,3, Yi Xin1,2, Harrilla Profka1, Hooman Hamedani1,2, Ian Duncan1, Stephen J Kadlecek1, Kai Ruppert1, and Rahim R. Rizi1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 3Surgery, University of Pennsylvania, Philadelphia, PA, United States

Lung volume reduction surgery (LVRS) treats emphysema by removing severely emphysematous regions of the lung. Techniques that can better identify which regions of the lung to remove as well as assess the resultant changes in lung function could lead to better surgical outcomes. Here, we explored the feasibility of using hyperpolarized xenon-129 (HXe) MRI for this purpose. Xenon polarization Transfer Contrast (XTC) imaging was used to quantify gas exchange as a metric for assessing the severity and distribution of emphysematous lung regions before and after LVRS.

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