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Abstract #2289

Quantifying Gas Exchange Rates Between Red Blood Cells and Airways Using Hyperpolarized Xenon-129

Faraz Amzajerdian 1,2, Stephen J Kadlecek1, Hooman Hamedani1,2, Yi Xin1,2, Ryan Baron1, Ian Duncan1, Maurizio Cereda1,3, Kai Ruppert1, and Rahim R. Rizi1
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 3Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Xenon Polarization Transfer Contrast (XTC) imaging is useful for quantifying the exchange rates between gas-phase and dissolved-phase xenon, particularly in emphysematic lungs which experience reduced local tissue and blood volumes. However, this technique does not account for local gas volumes, which can provide important context for interpreting these exchange rates. In this work, a method of incorporating both gas exchange rates and local gas volumes is described.

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