Abstract #2289

Quantifying Gas Exchange Rates Between Red Blood Cells and Airways Using Hyperpolarized Xenon-129

Faraz Amzajerdian ^1,2, Stephen J Kadlecek¹, Hooman Hamedani^1,2, Yi Xin^1,2, Ryan Baron¹, Ian Duncan¹, Maurizio Cereda^1,3, Kai Ruppert¹, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Xenon Polarization Transfer Contrast (XTC) imaging is useful for quantifying the exchange rates between gas-phase and dissolved-phase xenon, particularly in emphysematic lungs which experience reduced local tissue and blood volumes. However, this technique does not account for local gas volumes, which can provide important context for interpreting these exchange rates. In this work, a method of incorporating both gas exchange rates and local gas volumes is described.

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