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Abstract #2293

Quantitative Assessment of Lung Compliance using both Hyperpolarized 129Xe MRI and Micro-CT

Hongchuang Li1, Ming Zhang1, Haidong Li1, Xiuchao Zhao1, Qiuchen Rao1, Xiaoling Liu1, Yeqing Han1, Xianping Sun1, Xinrui Wang2, Chaohui Ye1, Xin Lou2, and Xin Zhou1
1Wuhan Institute of Physics and Mathematics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China, 2Department of Radiology, Chinese PLA General Hospital, Beijing, P. R. China, Beijing, China

Lung compliance is commonly used in clinical diagnosis of pulmonary fibrosis and emphysema, and it is generally measured using pulmonary function tests (PFTs) in clinic. In this study, the imaging methods including both hyperpolarized 129Xe MRI and micro-CT were used to quantify lung compliance in rats, and the significant correlation was found between these two imaging methods. Our study also demonstrates the feasibility of measuring lung compliance using hyperpolarized 129Xe MRI, which would contribute to fully understanding the lung function changes caused by the pulmonary diseases.

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