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Abstract #2294

Quantitative Evaluation of Changes in Lung Compliance Caused by Fibrosis using Hyperpolarized Gas MRI

Ming Zhang1, Haidong Li1, Hongchuang Li1, Xiuchao Zhao1, Yeqing Han1, Xianping Sun1, Chaohui Ye1, and Xin Zhou1
1National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China

Pulmonary compliance is generally measured using pulmonary function tests (PFTs) in clinical practice. In this study, we proposed a strategy of quantifying pulmonary compliance (Cst-Xe) using hyperpolarized (HP) 129Xe MRI. The Cst-Xe reliably distinguishes the healthy and bleomycin rats, and was correlated well with pulmonary compliance via PFTs and microstructure parameters via HP 129Xe DWI, respectively. The results have demonstrated the feasibility of HP 129Xe MRI in quantitatively and non-invasively assessing the pulmonary compliance, and also have improved the understanding of the lung compliance changes in fibrosis.

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