Abstract #2294

Quantitative Evaluation of Changes in Lung Compliance Caused by Fibrosis using Hyperpolarized Gas MRI

Ming Zhang¹, Haidong Li¹, Hongchuang Li¹, Xiuchao Zhao¹, Yeqing Han¹, Xianping Sun¹, Chaohui Ye¹, and Xin Zhou¹

¹National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China

Pulmonary compliance is generally measured using pulmonary function tests (PFTs) in clinical practice. In this study, we proposed a strategy of quantifying pulmonary compliance (Cst-Xe) using hyperpolarized (HP) ¹²⁹Xe MRI. The Cst-Xe reliably distinguishes the healthy and bleomycin rats, and was correlated well with pulmonary compliance via PFTs and microstructure parameters via HP ¹²⁹Xe DWI, respectively. The results have demonstrated the feasibility of HP ¹²⁹Xe MRI in quantitatively and non-invasively assessing the pulmonary compliance, and also have improved the understanding of the lung compliance changes in fibrosis.

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