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Abstract #2303

Assessment of the Ventilation Rate allows for Interindividual Comparability of Ventilation Inhomogeneity in Functional 3D-UTE Lung MRI

Julius Frederik Heidenreich1, Andreas Max Weng1, Corona Metz1, Thomas Benkert2, Helge Hebestreit3, Thorsten Alexander Bley1, Herbert Köstler1, and Simon Veldhoen1
1Department of Diagnostic and Interventional Radiology, University Hospital Wurzburg, Wurzburg, Germany, 2Application Development, Siemens Healthcare GmbH, Würzburg, Germany, 3Department of Pediatrics, University Hospital Wurzburg, Wurzburg, Germany

Lung imaging with single-breath-hold 3D-UTE MRI allows for lung function analyses such as fractional ventilation (FV). Despite being a promising technique for unenhanced functional imaging, its limited interindividual comparability due to variable breathing depths has been a major drawback. Referencing the voxelwise FV to the mean FV (entire lung) provides the ventilation rate, which can be used for inter-/intraindividual comparison. We demonstrate that the distribution width of the ventilation rate strongly correlates to the ventilation inhomogeneity in patients with cystic fibrosis as measured by the lung clearance index, which makes it a promising parameter for analysis of lung ventilation.

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