Application of first pass imaging to the lung is a promising technique. The majority of works apply a Singular Value Decomposition (SVD) with or without a prior fit to a gamma variate function to the concentration-time curve. In this study we compare lung perfusion quantification with and without 2 versions of the gamma-variate fitting in data from 66 patients with Interstitial lung disease. We found that the presence and choice of gamma variate fitting has an influence on perfusion parameters, but this is generally very small, except for mean transit time, suggesting that these approaches are broadly equivalent in practice.
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