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Abstract #2305

Repeatability and correlation of hyperpolarized xenon-129 and oxygen enhanced MRI parameters in healthy volunteers

Paul J.C. Hughes1, Marta Tibiletti2, Matthew J. Heaton2, Ho-Fung Chan1, Guilhem J. Collier1, Matthew Austin1, Laurie J. Smith1,3, Jim Lithgow1, Josephine H. Naish2,4, Jim M. Wild1,5, and Geoff J.M. Parker2,6
1POLARIS, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom, 2Bioxydyn, Manchester, United Kingdom, 3Sheffield Children's Hospital NHS Foundation Trust, Sheffield, United Kingdom, 4Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom, 5Insigneo Institute for in silico Medicine, The University of Sheffield, Sheffield, United Kingdom, 6Centre for Medical Image Computing, University College London, London, United Kingdom

Hyperpolarised xenon-129 MRI has shown utility in longitudinal assessment of lung structure and function, and has been shown to be a repeatable method. Oxygen enhanced MRI is a cheaper method of imaging different aspects of lung function. This work aimed to assess a single-centre repeatability of multiple metrics from both imaging methods in volunteers, and assess any correlations between xenon-129 and oxygen enhanced metrics of lung function.

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