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Abstract #2311

Quantification of Hyperpolarized 129-Xe signal fluctuations in a rodent chest restriction modelĀ 

Tahmina S Achekzai1, Steve J Kadlecek1, Yi Xin2,3, Federico Sertic2,4, Luis Loza2, Faraz Amzajerdian 2,3, Kai Ruppert2, Harrilla Profka2, Ian Duncan2, and Rahim R. Rizi2
1UPenn, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 4Surgery, University of Pennsylvania, Philadelphia, PA, United States

We demonstrated a new imaging technique capable of quantifying Xe gas uptake into airways and parenchyma over the course of a breathing cycle. Most current imaging techniques acquire entire images at a single breathing point. These methods may not replicate organ function during tidal breathing, and could potentially miss diagnostically important dynamic information depending on the time of acquisition. This sequence traverses the k-space over a series of 576 breaths to produce 12 images at different time points. Three healthy rats were imaged, and Xe signal was found to fluctuate at different times and amplitudes depending on respective lung compartment.

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