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Abstract #2340

Simultaneously acquired DWI and PET for early prediction of pathological response to neoadjuvant chemotherapy in breast cancer

Yee-Fan Lee1, Jo-Yu Chen1, Ning Chien1, Emi Niisato2, Robert Grimm3, Chiao Lo4, Ming-Yang Wang4, Chiun-Sheng Huang4, and Yeun-Chung Chang1
1Department of Medical Imaging, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan, 2Siemens Healthcare Limited, Taipei, Taiwan, 3Siemens Healthcare, Erlangen, Germany, 4Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan

Neoadjuvant chemotherapy (NAC) for treatment of breast cancer has the potential benefit of reducing tumor size before surgery. The response to NAC may also provide prognostic information which may lead to more effective chemotherapy. Combining PET and MRI information is useful for assessing the tumor response to NAC in a comprehensive manner. In this study, we performed texture analysis which indicated that the entropy of ADC and difference entropy of SUV were related and can be used to predict pCR with high areas under the receiver operating characteristic curve (AUC).

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