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Abstract #2341

Rapid 3D B1+-Compensated, Simultaneous Whole Breast T1, T2, and Apparent Diffusion Coefficient Quantification with MR Multitasking

Sen Ma1,2, Anthony G. Christodoulou2, Nan Wang1,2, and Debiao Li1,2
1Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Quantitative relaxation and diffusion mapping are desirable in clinical breast MRI as biomarkers for tissue characterization and prediction of treatment response. Conventional multi-parametric mappings are typically acquired in separate scans. We simultaneously generate high quality, co-registered T1/T2/ADC maps without image distortion for 3D whole breast coverage in 8.5min, incorporating B1+ compensation into the Multitasking framework to improve T1 accuracy. We demonstrate excellent agreement of T1/T2/ADC measurements between the proposed Multitasking approach and available reference methods, as well as good repeatability. We also show that all T1/T2/ADC measurements produced by the Multitasking framework agree with literature range.

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