Abstract #2364

Quantify the Progression of Acute Lung Injury Induced by Lipopolysaccharide with Hyperpolarized 129Xe MR

Haidong Li¹, Ming Zhang¹, Hongchuang Li¹, Xiuchao Zhao¹, Yeqing Han¹, Xianping Sun¹, Chaohui Ye¹, and Xin Zhou¹

¹National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China

CT and PET should not be performed on patient repeatedly in short-term for monitoring the progression of diseases since the ionizing radiation and radioactivity. Herein, we tried to demonstrate the feasibility of hyperpolarized ¹²⁹Xe MR for monitoring the progression of acute lung injury (ALI) in rats. Our results indicated hyperpolarized ¹²⁹Xe MR has the potential to monitor the progression of ALI in rats.

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