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Abstract #2369

The Impact of T2* And Pulmonary Gas Exchange on The Accuracy Of The Applied Dissolved-phase Flip Angle in Hyperpolarized Xenon-129 MRI?

Yiwen Qian1, Kai Ruppert1, Faraz Amzajerdian1, Yi Xin1, Hooman Hamedani1, Luis Loza1, Tahmina S. Achekzai1, Ryan J. Baron1, Ian F. Duncan1, Harrilla Profka1, Mehrdad Pourfathi1, Federico Sertic1, Stephen Kadlecek1, and Rahim R. Rizi1
1Radiology, University of Pennsylvania, Philadelhia, PA, United States

The fleeting nature of hyperpolarized xenon-129 magnetization necessitates a separate flip angle calibration procedure based on the decay of the gas-phase signal. This calibration is subsequently assumed to be valid for imaging of the xenon dissolved in the lung tissue despite the rapid exchange between the parenchyma and the alveolar gas volume and despite that the T2* is much shorter in the former than in the latter. In this work we implemented a 1-dimensional gas exchange simulation and investigated to what extent the effective flip angle at the dissolved-phase frequencies is affected by exchange and acquisition parameters.

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