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Abstract #2368

Does Pulmonary Gas Transport Affect Spatially-Resolved Alveolar Septal Wall Thickness Measurements with Hyperpolarized Xenon-129 MRI?

Kai Ruppert1, Faraz Amzajerdian1, Yi Xin1, Hooman Hamedani1, Luis Loza1, Tahmina S. Achekzai1, Ryan J. Baron1, Ian F. Duncan1, Harrilla Profka1, Yiwen Qian1, Mehrdad Pourfathi1, Federico Sertic1, Stephen Kadlecek1, and Rahim R. Rizi1
1Radiology, University of Pennsylvania, Philadelhia, PA, United States

Septal wall thickness (SWT) measurements with hyperpolarized xenon-129 (HXe) MRI are typically conducted as spectroscopic acquisitions that lack spatial information. Recently, efforts have been made to obtain spatial maps of SWT. Here, we investigated differences in apparent lung physiology between peripheral and central lung regions and found an implausible change in observed capillary transit time and SWT from the periphery to the center of the lungs. This effect is likely caused by the transport of xenon-saturated blood towards the heart, and is not based on physiological differences, thus requiring a fundamental revision of analytical gas uptake models.

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