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Abstract #2367

Phase imaging of hyperpolarized 129Xe gas in a human lung

Gang Zheng1, Wai Tung Lee2,3, Xin Tong4, Tim D’Adam2, Steven Parnell5, Michael de Veer1, Shenpeng Li1, Hongxin Wang1, Richard Mcintyre1, Francis Thien6, and Gary Egan1
1Monash Biomedical Imaging, Monash University, Clayton, Australia, 2Australian Nuclear Science and Technology Organisation, Lucas Heights, Australia, 3Instrument Technologies Division, European Spallation Source ERIC, Lund, Sweden, 4China Spallation Neutron Source, Dongguan, China, 5Delft University of Technical, Delft, Netherlands, 6Eastern Clinical School, Monash University, Box Hill, Australia

We describe a custom-designed spin-exchange-optical pumping (SEOP) polarizer which can reliably produce hyperpolarized 129-Xe (HP-Xe) gas. Imaging of a HP-Xe phantom showed phase images were less sensitive to depolarization and could provide on/off images of HP-Xe. In a human lung, phase image provided higher imaging contrast in low HP-Xe polarization states.

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