Abstract #2366

Investigation of Lung Injury Caused by Air pollutants PM2.5 with both Pulmonary Function Tests and Hyperpolarized 129Xe MR

Ming Zhang¹, Haidong Li¹, Hongchuang Li¹, Xiuchao Zhao¹, Qian Zhou¹, Qiuchen Rao¹, Yeqing Han¹, Yina Lan², He Deng¹, Xianping Sun¹, Xin Lou², Chaohui Ye¹, and Xin Zhou¹

¹National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China, ²Department of Radiology, Chinese PLA General Hospital, Beijing, China

In this study, hyperpolarized ¹²⁹Xe MR and pulmonary function tests were utilized to quantitatively evaluate the pulmonary physiological changes caused by air pollutants (PM_2.5), which are difficult to be non-invasively assessed using the conventional methods including bronchoalveolar lavage fluid analysis and histopathological sections. Significant differences were found in mean exchange time constant, septal wall thickness and TP/GAS ratio using ¹²⁹Xe dynamic spectra. The results from our study indicated hyperpolarized ¹²⁹Xe MR may be a promising method for quantifying lung injury caused by air pollution in clinic.

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