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Abstract #2366

Investigation of Lung Injury Caused by Air pollutants PM2.5 with both Pulmonary Function Tests and Hyperpolarized 129Xe MR

Ming Zhang1, Haidong Li1, Hongchuang Li1, Xiuchao Zhao1, Qian Zhou1, Qiuchen Rao1, Yeqing Han1, Yina Lan2, He Deng1, Xianping Sun1, Xin Lou2, Chaohui Ye1, and Xin Zhou1
1National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China, 2Department of Radiology, Chinese PLA General Hospital, Beijing, China

In this study, hyperpolarized 129Xe MR and pulmonary function tests were utilized to quantitatively evaluate the pulmonary physiological changes caused by air pollutants (PM2.5), which are difficult to be non-invasively assessed using the conventional methods including bronchoalveolar lavage fluid analysis and histopathological sections. Significant differences were found in mean exchange time constant, septal wall thickness and TP/GAS ratio using 129Xe dynamic spectra. The results from our study indicated hyperpolarized 129Xe MR may be a promising method for quantifying lung injury caused by air pollution in clinic.

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