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Abstract #2379

Use of a Digital Reference Object for Validation of Advanced Reconstruction Methods in High Spatial-temporal Resolution Breast DCE-MRI

Ping N Wang1, Julia V Velikina1, Roberta M Strigel1,2,3, Leah C Henze Bancroft2, Ty A Cashen4, Kevin M Johnson1, Alexey A Samsonov2, Ali Ersoz5, Edward F Jackson1,2,3, and James H Holmes2
1Department of Medical Physics, University of Wisconsin Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin Madison, Madison, WI, United States, 3Carbone Cancer Center, University of Wisconsin Madison, Madison, WI, United States, 4Global MR Applications & Workflow, GE Healthcare, Madison, WI, United States, 5MR Engineering, GE Healthcare, Waukesha, WI, United States

Advanced data acquisition and reconstruction methods have been proposed to improve temporal and spatial resolution DCE imaging for breast. However, validation and comparison of these methods against a known truth is challenging. In this work we propose a digital reference object for breast pharmacokinetic simulation to evaluate different advanced reconstructions including MOCCO and iGRASP. The approach allowed comparison of the reconstructed temporal characteristics including pharmacokinetic analysis using different reconstruction parameters against the assigned ground truth. Spatial sharpness was also measured to compare with reference fully sampled images.

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