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Abstract #2386

Advances in 3D High-Speed MR Spectroscopic Imaging for Monitoring Neoadjuvant Chemotherapy in Breast Cancer

Stefan Posse1, Ingrid Lane2, Bruno Sa De La Rocque Guimaraes1, Bernard Twafik3, and Ursa Brown-Glaberman3
1Neurology, University of New Mexico, Albuquerque, NM, United States, 2Mind Research Network, Albuquerque, NM, United States, 3Division of Hematology / Oncology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, United States

Three patients with biopsy-confirmed, infiltrating ductal carcinoma were studied at 3 Tesla to monitor changes in total Choline during neoadjuvant chemotherapy in comparison with dynamic contrast enhanced MRI. A novel bilateral high-speed 3D Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) protocol with integrated water reference acquisition mapped decreases in total Choline early during treatment in 2 HER2-negative patients with partial pathologic response, but not in the third HER2-positive patient. Surgical clip related B0-inhomogeneity impacted both PEPSI and DCE-MRI measurements. To address this limitation, we developed a novel expanded k-space encoding approach for PEPSI and demonstrated signal recovery in tissue regions affected by dephasing.

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