The preoperative prediction of EPE has a profound impact on treatment decision making, however, it still remains challenging presently. In this study, we compared the radiomics signatures extracted from different MR sequences to diagnose EPE. The radiomics signature based on DWI showed better performance for EPE prediction among mpMRI sequences. The radiomics model based on DWI, T2WI and DCE images was demonstrated feasible for the prediction of EPE. But the added value of clinical variables to the radiomics model was not prominent.