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Abstract #2398

Characterization of the Metabolomic Signature of Prostate Cancer by Mass Spectrometry and Magnetic Resonance Spectroscopy of Urine

Leo L. Cheng1, Andrew Gusev1, Alex Buko2, Takushi Oga2, and Adam S. Feldman1
1MGH/Harvard, Boston, MA, United States, 2Human Metabolome Technologies, Boston, MA, United States

We used Capillary Electrophoresis Time of Flight Mass Spectrometry and Magnetic Resonance Spectroscopy to analyze urine from men undergoing prostate biopsy to investigate their metabolomic profiles and look for potential biomarkers. CE-MS analysis identified 60 metabolites that were statistically different between urine samples of men with PCa and PCa-free men and had overlap with MRS. Pathway analysis of these showed high activity in ceramide, short chain fatty acid (SCFA), branched chain amino acid, serine, threonine and tryptophan metabolism. Targeted studies of these metabolites are underway in our lab; if validated, they have potential to serve as non-invasive biomarkers for PCa.

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