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Abstract #2410

R2* yield by IDEAL IQ MRI in Evaluating the Expression Status of Glypican-3 in Hepatocellular Carcinoma

Rushi Chen1, Yan Bai2, Ge Zhang2, Kaiyu Wang3, and Meiyun Wang2
1Henan provincial people's hospital& Zhengzhou University People’s Hospital, Zhengzhou, China, 2Henan provincial people's hospital, Zhengzhou, China, 3GE Healthcare, MR Research, Beijing, China

Accurate diagnosis and evaluation of HCC is important for improving the efficiency of HCC treatment and patient prognosis. Glypican-3 (GPC3) has been considered as a promising diagnostic and prognostic biomarker and a target for immune-therapeutic in HCC. Our study aimed to investigate the utility of IDEAL IQ MRI to prospectively evaluate the expression status of GPC3. Our results showed that the intratumoral R2* value was significantly higher in the positive-GPC3 HCC patients than in the negative-GPC3 HCC patients (P=0.003). The IDEAL IQ MRI may have potential for non-invasively predict GPC3 expression status.

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