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Abstract #2417

Differentiation of Prostate Cancer from Benign Prostatic Hyperplasia using Whole-lesion Histogram Analysis on Diffusion-weighted Imaging

Luguang Chen1, Pengyi Xin1, Qingsong Yang1, Tao Song1, Chao Ma1, Robert Grimm2, Caixia Fu3, and Jianping Lu1
1Radiology, Changhai Hospital of Shanghai, Shanghai, China, 2Application Predevelopment, Siemens Healthcare, Erlangen, Germany, 3Application Development, Siemens Shenzhen Magnetic Resonace Ltd, Shenzhen, China

Histogram and texture analysis have the potential in evaluating the heterogeneous features of tumors. This study aimed to assess the usefulness of histogram and texture analysis of ADC maps for differentiating PCa from BPH with pathology as the reference. 90 PCa and 112 BPH patients were enrolled and analyzed using histogram and texture analyses. Significant differences were observed in age, PSA, lesion volume and histogram parameters (except kurtosis) of ADC map between the PCa and BPH patients. The whole-lesion histogram and texture analysis-based parameters from the quantitative ADC map may serve as a useful biological characterization of prostate cancer.

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