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Abstract #2426

Amide proton transfer MR imaging of prostate cancer: a preliminary study using 3D acquisition

Ayumu Kido1, Tsutomu Tamada1, Yu Ueda2, Tomohiro Mochizuki3, Takeshi Fukunaga1, and Akira Yamamoto1
1Radiology, Kawasaki Medical School, Kurashiki, Japan, 2Philips Japan, Minato-ku, Japan, 3Philips Japan, Osaka, Japan

APT-MRI is a contrast-agent-free MRI technique that exploits signal from the amide protons (NH groups) contained in proteins and peptides. No studies have reported the use of 3DAPT. Quantitative analysis (ADC and APT SI (%)) were calculated for PC lesions and for benign regions that included normal PZ and benign prostatic lesions. APT SI was comparable among normal regions, benign lesions, and PC. However, APT SI was significantly higher in large PC than in small PC. In addition, the APT SIs of PC lesions correlated well with PSA. APT SI may represent tumor volume, PC staging, and prognosis.

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