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Abstract #2460

Spin-lock MRI Reveals Tubular Dilation and Fibrosis after Unilateral Ureter Obstruction

Feng Wang1,2, Tadashi Otsuka3, Keiko Takahashi3, Daniel C. Colvin1, Hua Li1, Raymond C. Harris3, Takamune Takahashi3, and John C. Gore1,2,4
1Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, United States, 4Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Assessing the severity and progression of tubular dilation and fibrosis in kidneys are important clinical challenges. Here we evaluate spin-lock MR imaging with different locking fields for detecting tubular dilation and fibrosis in a mouse model of unilateral ureter obstruction. We fit the dispersion of spin-lock relaxation rates R at different locking fields (frequencies) to a model of exchanging water pools and assessed the sensitivity of the derived quantities for detecting tubular dilation and fibrosis in kidney. Histological scores for tubular dilation and fibrosis, based on luminal space and positive picrosirius red area in sections, were obtained for comparison.

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