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Abstract #2461

Towards non-invasive measurement of renal tubule size by diffusion MRI

Darya Morozov1, Jennifer R. Charlton2, Kimberly A. deRonde2, and Kevin M. Bennett1
1Radiology, Washington University in St. Louis, School of Medicine, Saint Louis, MO, United States, 2Pediatrics, University of Virginia Children's Hospital, Charlottesville, VA, United States

Tubular hypertrophy is an early feature of many renal pathologies. A direct, non-invasive measure of kidney morphology is lacking. Current diagnostics are primarily based on biopsy after suspected renal disease, which is prone to sampling error and is invasive. A robust non-invasive imaging tool to study tubular changes in vivo is greatly needed and would provide early tissue biomarker for initiation and progression of kidney injury. In this work, we used a single diffusion encoding MRI approach to study distribution of restricting tissue compartment sizes in kidney cortex as a potential noninvasive marker of tubule size in the intact kidney.

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