This study evaluated if multiparametric magnetic resonance imaging (MRI) could identify changes in warm ischemia-reperfusion injury (WIRI) after liposomal prostaglandin E1 (Lipo-PGE1) intervention in rabbit livers. We measured blood oxygen level–dependent, diffusion tensor, and intravoxel incoherent motion imaging on functional hepatic parameters in rabbits exposed to 1) warm ischemia at different times, 2) Lipo-PGE1 interventions, and 3) sham operations. The parameters were sensitive to perfusion and oxygenation changes during WIRI. Multiparametric MRI successfully identified changes after Lipo-PGE1 intervention. These results offer new insights to quantitatively evaluate the effect of drugs on hepatic WIRI after liver transplantation and hepatectomy.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords