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Abstract #2480

Limits of Fat Quantification with Chemical Shift Encoded Magnetic Resonance Imaging in the Presence of Iron Overload

Timothy J Colgan1, Diego Hernando1,2, and Scott B Reeder1,2,3,4,5
1Radiology, University of Wisconsin - Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 3Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 4Medicine, University of Wisconsin - Madison, Madison, WI, United States, 5Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States

Quantitative confounder-corrected chemical shift encoded MRI estimates of proton density fat fraction (PDFF) are corrected for R2* signal decay. However, at very high levels of iron overload, the observed signal in CSE-MRI decays rapidly (high R2*), complicating the separation of water and fat signals, and therefore the quantification of PDFF. This work characterized the degree of iron overload above which the quantification of PDFF is limited and developed practical clinical and research guidelines for PDFF estimation protocol design for 1.5T and 3.0T.

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