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Abstract #2488

A unified model for hepatobiliary transporter function assessment using Gadoxetate DCE-MRI

Sirisha Tadimalla1,2 and Steven Sourbron2,3
1Institute of Medical Physics, University of Sydney, Sydney, Australia, 2Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom, 3Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

A variety of models for Gadoxetate DCE-MRI in the liver has been proposed, but comparing results of different groups is difficult due to a lack of consistency in the definitions, nomenclature and units. We perform a rigorous classification of existing models and definitions by defining a general unified Gadoxetate DCE-MRI liver model, and identifying the relationship with existing models. Six distinct models were identified in the literature and a translation table was derived to allow direct comparison of measured quantities. The method provides a rational basis for a new standard in this field.

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