Abstract #2496

A Fast 3D MR Elastography Sequence for Measurement of Liver Stiffness in One Breath Hold

Hui Wang^1,2,3, Amol Pednekar^2,3, Jean A. Tkach^2,3, Charles L. Dumoulin^2,3, Kaley R. Bridgewater², Andrew T. Trout^2,3, and Jonathan R. Dillman^2,3

¹Philips, Cincinnati, OH, United States, ²Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, ³Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States

We describe a 3D fast field echo (FFE) Magnetic Resonance Elastography (MRE) pulse sequence for measurement of liver stiffness in a single breath hold. The key features of the sequence include: 1) 3D acquisition; 2) mechanical wave magnitude labelling of 1.5 cycles of motion for each RF excitation; 3) flow saturation pre-pulses to suppress vascular flow; and 4) pseudorandom undersampling of k-space with Compressed SENSE reconstruction. The technique was validated in two gel phantoms with different stiffness and used to measure liver stiffness in five volunteers.

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