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Abstract #2496

A Fast 3D MR Elastography Sequence for Measurement of Liver Stiffness in One Breath Hold

Hui Wang1,2,3, Amol Pednekar2,3, Jean A. Tkach2,3, Charles L. Dumoulin2,3, Kaley R. Bridgewater2, Andrew T. Trout2,3, and Jonathan R. Dillman2,3
1Philips, Cincinnati, OH, United States, 2Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 3Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States

We describe a 3D fast field echo (FFE) Magnetic Resonance Elastography (MRE) pulse sequence for measurement of liver stiffness in a single breath hold. The key features of the sequence include: 1) 3D acquisition; 2) mechanical wave magnitude labelling of 1.5 cycles of motion for each RF excitation; 3) flow saturation pre-pulses to suppress vascular flow; and 4) pseudorandom undersampling of k-space with Compressed SENSE reconstruction. The technique was validated in two gel phantoms with different stiffness and used to measure liver stiffness in five volunteers.

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