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Abstract #2495

A Fast MR Elastography Sequence with Interleaved Inflow Saturation and Compressed SENSE

Hui Wang1,2,3, Amol Pednekar2,3, Jean A. Tkach2,3, Kaley R. Bridgewater2, Andrew T. Trout2,3, Jonathan R. Dillman2,3, and Charles L. Dumoulin2,3
1Philips, Cincinnati, OH, United States, 2Department of Radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, 3Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States

We describe a fast field-echo Magnetic Resonance Elastography pulse sequence to measure liver stiffness in less than half the breath hold time (≈6.3 sec/slice) of the conventional implementation. Key features include: 1) non-alternating motion encoding gradients to allow a shorter TR while maintaining appropriate gradient waveform polarity synchronization with the applied mechanical motion; 2) interleaved flow saturation pre-pulses to suppress flow; and 3) pseudorandom undersampling k-space with Compressed SENSE reconstruction. The technique was validated in two gel phantoms differing in stiffness and used to evaluate liver stiffness in five volunteers.

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