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Abstract #2494

Assessing the variation of MR and non-invasive markers in compensated cirrhosis: insights for assessing disease progression

Chris R Bradley1,2, Eleanor F Cox1,2, Naaventhan Palaniyappan2, Guruprasad P Aithal2, I Neil Guha2, and Susan T Francis1,2
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom

Baseline multi-organ MRI measures of structure and haemodynamics in the liver, spleen, heart and kidneys were collected in healthy volunteers, compensated cirrhosis (CC) and decompensated cirrhosis patients to benchmark the change in measures with disease severity. In a stable CC cohort, observed annually for 3 years, we show liver T1, liver perfusion, superior mesenteric artery flow, spleen perfusion, and renal cortex T1 (measures that predict negative liver related outcomes) have sufficient resolution to track disease progression.

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