Abstract #2498

Comparison Of GraSE Versus FSE T2 Mapping In The Liver And Correlation With Histologic Fibrosis Stage In Pediatric Autoimmune Liver Disease

Deep B. Gandhi¹, Jonathan Dudley¹, Ruchi Singh², Jean A. Tkach¹, Divya Sharma³, Amy Taylor², Alexander G. Miethke², and Jonathan R. Dillman¹

¹Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Division of Hepatology, Gastroenterology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ³Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH, United States

Autoimmune liver diseases can lead to hepatic fibrosis which, when progressive, can lead to liver failure ultimately requiring transplantation. In this study 31 patients with autoimmune liver diseases underwent conventional and GraSE T2 mapping at 1.5T as well as liver biopsy with histologic fibrosis staging. Significant positive correlations between GraSE and conventional liver T2 measurements were observed for the weighted mean of all slices (r=0.80; p<0.0001) and for individual slices from all subjects (r=0.72; p<0.0001). Conventional T2 measurements were higher, on average, than GraSE T2 measurements. There was no significant correlation observed between liver T2 measurements and histologic fibrosis stage.

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