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Abstract #2499

Comparison of T1rho and Diffusion Kurtosis Imaging in Evaluation of Hepatic Sinusoidal Obstruction Syndrome in Rats

Jian Lyu1,2, Guixiang Yang3,4, Yingjie Mei5, Li Guo1,2,6, Yihao Guo1,2, Kaixuan Zhao1, Xinyuan Zhang1,2, Yikai Xu3,4, and Yanqiu Feng1,2
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, 3Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, 4Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, China, 5Philips Healthcare, Guangzhou, China, 6Department of MRI, The First People’s Hospital of Foshan (Affiliated Foshan Hospital of Sun Yat-sen University), Foshan, China

T1rho represents the spin-lattice relaxation time constant in the rotating frame, which sever as a biomarker for liver function associated with alteration in the macromolecular content of tissues. Diffusion kurtosis imaging (DKI) was developed to measure non-Gaussian diffusion, which have increasingly been used to characterize microstructural heterogeneity in vivo. Sinusoidal obstruction syndrome (SOS) is a dynamic process with complex histopathological changes in liver. Our study attempts to investigate the relationship between T1rho and DKI parameters in the light of pathological examinations to help us better understand the contribution of the possible factors to changes in T1rho.

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