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Abstract #2514

Quantification of pancreatic volume and clinical correlations in patients with hemoglobinopathies

Antonella Meloni1, Massimiliano Missere2, Gennaro Restaino2, Laura Pistoia1, Vincenzo Positano1, Emanuele Grassedonio3, Nicolò Schicchi4, Giuseppe Peritore5, Francesco Massei6, Nicola Dello Iacono7, Angelica Barone8, and Alessia Pepe1
1MRI Unit, Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, 3Policlinico "Paolo Giaccone", Palermo, Italy, 4Azienda Ospedaliero-Universitaria Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy, 5"ARNAS" Civico, Di Cristina Benfratelli, Palermo, Italy, 6Azienda Ospedaliero Universitaria Pisana – Stabilimento S.Chiara, Pisa, Italy, 7Ospedale Casa Sollievo della Sofferenza IRCCSOspedale Casa Sollievo della Sofferenza IRCCS, San Giovanni Rotondo, Italy, 8Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

In patients with hemoglobinopathies fat infiltration is a common finding and pancreatic volume is significantly lower than in normal subjects but it is not associated to age or gender. Pancreatic iron overload is present in the 74% of the patients and it is associated with reduced pancreatic volume. Patients with diabetes have a lower pancreatic volume.

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