The resectability and pathological grade of pancreatic cancer are important for prognosis of patients. We try to predict the pathological grade and the resectability of pancreatic cancer by quantitative IVIM-DWI. Comparing the IVIM parameters of resectable and unresectable pancreatic cancer, poorly differentiated and highly-moderately differentiated pancreatic cancer, we found that poorly differentiated pancreatic cancer had lower f value than highly-moderately differentiated pancreatic cancer, and resectable pancreatic cancer had higher d, f values than unresectable pancreatic cancer. The quantitative IVIM parameters can predict the resectability and pathological stage of pancreatic cancer, which can be helpful for assessment of resectability.