Abstract #2535

Free-Breathing QSM and R2* Mapping of Hepatic Iron Overload Using a 3D Multi-Echo Cones Trajectory

Youngwook Kee¹, Christopher M. Sandino², Joseph Y. Cheng¹, Timothy Colgan³, Diego Hernando³, Ann Shimakawa⁴, and Shreyas S. Vasanawala¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Electrical Engineering, Stanford University, Stanford, CA, United States, ³Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁴GE Healthcare, Redwood City, CA, United States

In this study, free-breathing QSM and R2* mapping of liver iron overload was enabled using a 3D multi-echo cones trajectory. The proposed method was compared with a chemical-shift-encoded MRI technique that requires breath-holding. QSM and R2* exhibit similar image quality in axial, sagittal, and coronal views as well as good agreement in ROI-based quantitative value based on Bland-Altman and linear correlation plots. The imaging time for free-breathing liver iron quantification takes ~4 min, which can be further accelerated by increasing readout duration or using compressed sensing.

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