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Abstract #2535

Free-Breathing QSM and R2* Mapping of Hepatic Iron Overload Using a 3D Multi-Echo Cones Trajectory

Youngwook Kee1, Christopher M. Sandino2, Joseph Y. Cheng1, Timothy Colgan3, Diego Hernando3, Ann Shimakawa4, and Shreyas S. Vasanawala1
1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering, Stanford University, Stanford, CA, United States, 3Radiology, University of Wisconsin-Madison, Madison, WI, United States, 4GE Healthcare, Redwood City, CA, United States

In this study, free-breathing QSM and R2* mapping of liver iron overload was enabled using a 3D multi-echo cones trajectory. The proposed method was compared with a chemical-shift-encoded MRI technique that requires breath-holding. QSM and R2* exhibit similar image quality in axial, sagittal, and coronal views as well as good agreement in ROI-based quantitative value based on Bland-Altman and linear correlation plots. The imaging time for free-breathing liver iron quantification takes ~4 min, which can be further accelerated by increasing readout duration or using compressed sensing.

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