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Abstract #2536

Histological Validation of Multipeak Fat-Corrected Complex R2* Mapping for Quantification of Liver Iron

Collin J Buelo1,2, Jing Zhou3, Ante Zhu2,4, Kritisha Rajlawot5, Bingjun He5, Diego Hernando1,2, Jin Wang5, and Scott B. Reeder1,2,4,6,7
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Pathology, The third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, 4Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 5Radiology, The third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China, 6Medicine, University of Wisconsin-Madison, Madison, WI, United States, 7Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Histological grading of iron deposition in the liver has been shown to correlate with conventional magnitude-based R2* mapping methods. However, magnitude-based R2* mapping methods are known to exhibit bias in the presence of fat and when signal-to-noise ratio (SNR) is low. Multipeak fat-corrected complex R2* mapping enables accurate R2* measurements by correcting for fat-related bias and the bias due to low SNR, but has not been compared to histological iron grading. In this work, multipeak fat-corrected R2* mapping is validated by comparing with histological iron grading as the reference standard.

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