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Abstract #2537

Evaluation of severe hepatic iron overload using a high-performance 0.55T MRI system

Adrienne E Campbell-Washburn1, Christine Mancini1, Anna Conrey1, Lanelle Edwards1, Hui Xue1, Peter Kellman1, W. Patricia Bandettini1, and Swee Lay Thein1
1National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States

Iron overload in the liver can be assessed with MRI by measurements of T2* and R2*. In this study, we assessed the dynamic range of hepatic T2* values using a high-performance 0.55T, compared to 1.5T, in patients with iron overload. Patients with iron overload had increased dynamic range of T2* values at 0.55T (T2* = 11.8 ± 9.4ms) compared with 1.5T (T2* = 5.7 ± 6.0ms), and the measurements were closely correlated between 0.55T and 1.5T (r = 0.96). The improved field homogeneity at 0.55T may provide value for stratification and monitoring of patients with severe iron overload by T2*.

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