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Abstract #2538

Effect of noise on R2 based iron quantitation: Numerical simulation and phantom verification

Zili David Chu1,2 and Raja Muthupillai3
1Radiology, Baylor College of Medicine, MISSOURI CITY, TX, United States, 2Pediatric Radiology, Texas Children's Hospital, Houston, TX, United States, 3Radiology, Baylor St. Luke's Medical Center, Houston, TX, United States

T2/T2* based relaxometry is increasingly used to non-invasively quantify tissue iron content in lieu of biopsy. However, studies have shown that the observed linear relationship between R2 (1/T2) and tissue iron concentrations does not hold true above an iron concentration threshold (dubbed as the ‘saturation threshold’) [1,2]. Our numerical simulations and phantom experiments show that the choice of interval between the echo times used to sample T2 decay, and noise levels play a crucial role in determining the saturation threshold, and that the linear relationship between iron concentration and R2 can be extended by judiciously varying echo spacing.

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