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Abstract #2551

Investigation of Supraclavicular Brown Adipose Tissue in Hyperthyroid Patients using Simultaneous PET-MR Imaging

Sanjay K Verma1, Lijuan Sun2, Suresh Anand Sadananthan3, Navin Michael3, Hui Jen Goh2, Govindharajulu Priya2, Melvin Khee-Shing Leow2,4, and S Sendhil Velan1
1Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), Singapore, Singapore, 2Clinical Nutrition Research Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, 3Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, 4Department of Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore

BAT dissipates heat energy during adaptive thermogenesis regulated by several complex neuronal mechanisms including thyroid hormones. Twelve hyperthyroid subjects, treated with an anti-thyroid drug intervention were investigated using simultaneous PET-MR imaging. A significant increase in body weight and decrease in resting metabolic rate after treatment were observed. MR fat fraction significantly increased after treatment, whereas there is no significant change in PET-SUV. MR is more sensitive to the thyroid hormone induced changes, and can be utilized to study the BAT activity.

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