Abstract #2552

Evaluating a Community-Based Diet and Lifestyle Intervention For Improved Metabolic Health in India: A Pilot Randomized Controlled Trial (RCT)

Stephen Bawden^1,2, K Manoj³, Elizabeth Simpson¹, K Leena⁴, Moira Taylor¹, Sally Hibbert⁵, Amrita Vijay¹, Laura Miller¹, Jane Grove¹, Ana Valdes¹, Penny Gowland², Thrivikrama Shenoy⁴, and Guruprasad P Aithal¹

¹NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³Metro Scan and Laboratory, Trivandrum, India, ⁴Population Health and Research Institute, Trivandrum, India, ⁵Centre for Research in the Behavioural Sciences, Nottingham University Business School, Nottingham, United Kingdom

The Indian population provides important cohorts for research into metabolic disorders due to the greater prevalence of NAFLD and diabetes, and the relatively low complexity of dietary intake. In this study 71 male participants with NAFLD were recruited from a cohort in India and randomized into two groups - a 16 week low glycaemic index dietary intervention arm and a control arm. 1H MRS was used to assess liver fat fractions, alongside other metabolic markers. Results show a trend towards reduced fat fractions in the diet arm only.

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