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Abstract #2553

Using 1H MRS to Investigate Hepatic Fat Fractions and Lipid Composition in NAFLD Patients with Type 2 Diabetes

Stephen Bawden1,2, Scott Willis3, Aron Sherry3, Penny Gowland2, James King3, and Guruprasad P Aithal1
1NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom

1H MRS offers unique insights into hepatic lipid composition. In this study, NAFLD patients with and without Type 2 Diabetes were scanned and hepatic lipid composition indices measured. Diabetic patients then underwent a randomized controlled trial to investigate the effectiveness of 6 weeks moderate exercise vs control. Lipid composition indices were similar to previous studies in obesity, and show no differences in diabetic v non-diabetic groups. The intervention also shows no change in hepatic fat fraction or lipid composition.

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