Meeting Banner
Abstract #2554

Accumulation of saturated IMCL is associated with insulin resistance in both males and females

Laura Watson1, Katie Carr1, Claire Adams2, Jieniean Worsley1, Krishna K Chatterjee1,2, Leanne Hodson3, Chris Boesch4, Graham J Kemp5, David B Savage2, and Alison Sleigh1,2,6
1National Institute for Health Research Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 2Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom, 3Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom, 4Department of Clinical Research and Radiology, AMSM, University Bern, Bern, Switzerland, 5Department of Musculoskeletal Biology, and MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), University of Liverpool, Liverpool, United Kingdom, 6Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom

In females the accumulation of saturated IMCL is more strongly associated with whole-body insulin resistance than IMCL concentration alone. Using a recently-validated 1H MRS approach we studied both the IMCL composition and concentration independent of composition in 30 control males, 41 age- and BMI-matched female controls and 16 female insulin resistant lipodystrophic subjects. We demonstrate that in both males and females markers reflecting the accumulation of saturated IMCL are more strongly associated with whole-body insulin sensitivity than IMCL concentration alone.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here