Abstract #2554

Accumulation of saturated IMCL is associated with insulin resistance in both males and females

Laura Watson¹, Katie Carr¹, Claire Adams², Jieniean Worsley¹, Krishna K Chatterjee^1,2, Leanne Hodson³, Chris Boesch⁴, Graham J Kemp⁵, David B Savage², and Alison Sleigh^1,2,6

¹National Institute for Health Research Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ²Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom, ³Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom, ⁴Department of Clinical Research and Radiology, AMSM, University Bern, Bern, Switzerland, ⁵Department of Musculoskeletal Biology, and MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), University of Liverpool, Liverpool, United Kingdom, ⁶Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom

In females the accumulation of saturated IMCL is more strongly associated with whole-body insulin resistance than IMCL concentration alone. Using a recently-validated ¹H MRS approach we studied both the IMCL composition and concentration independent of composition in 30 control males, 41 age- and BMI-matched female controls and 16 female insulin resistant lipodystrophic subjects. We demonstrate that in both males and females markers reflecting the accumulation of saturated IMCL are more strongly associated with whole-body insulin sensitivity than IMCL concentration alone.

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