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Abstract #2556

Assessment of cardiac and liver metabolite changes in diabetic and DIAPH1 knockout mice using 1H-MRS and chemical-shift encoded MRI

Rajiv G Menon1, Dimitri Martel1, Nosirudeen Quadri2, Charlotte Detremmerie2, Laura Frye2, Ann Marie Schmidt2, Ravichandran Ramasamy2, and Ravinder R Regatte1
1Center for Biomedical Imaging, Department of Radiology, New York University Langone Health, New York, NY, United States, 2Department of Biochemistry and Molecular Pharmacology, Department of Medicine, New York University Langone Health, New York, NY, United States

Diabetes Mellitus causes systemic changes in a number of metabolites in multiple organs. Previous studies have shown that RAGE and its cytoplasmic domain partner Diaph1 are key mediators of metabolic and functional changes in diabetic mice. The goal of this study was to use 1H-MRS and CSE-MRI to investigate the metabolite and water-fat fraction changes in the liver and heart in wild type (WT), WT-diabetic (WT-DM) mice, and DIAPH1 knockout diabetic (DIAPH1 KO-DM) mice. The metabolite levels and water-fat distribution in the three cohorts suggest that DIAPH1 KO-DM mice, despite being diabetic, experience a protective effect owing to DIAPH1 deletion.

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