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Abstract #2559

Studying the effect of ambient temperatures on heat production of activated BAT in rats using magnetic resonance thermometry

Chuanli Cheng1, Qian Wan1, Yangzi Qiao1, Min Pan2, Changjun Tie1, Hairong Zheng1, Xin Liu1, and Chao Zou1
1Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shenzhen, China, 2Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, China

Cold exposure is the commonly used method in evaluating the brown adipose tissue (BAT) activation. In this study, the heat production capacity of BAT in rats housed at different ambient temperatures were evaluated using magnetic resonance thermometry after injecting norepinephrine (NE). The results show that the rats housed at lower ambient temperature (15°C) for 2 weeks have surprisingly lower temperature rise after NE injection, implying that long-term cold exposed rats have lower heat production capacity after drug activation.

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