Abstract #2558

Estimation of the triglyceride fatty acid composition in human adipose tissue using multi-TE and SHORTIE STEAM: in vitro validation using GC-MS

Stefan Ruschke¹, Dominik Weidlich¹, Julius Honecker ², Claudine Seeliger², Josef Ecker³, Olga Prokopchuk⁴, Hans Hauner², and Dimitrios C Karampinos¹

¹Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, ²Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany, ³ZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany, ⁴Department of Surgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany

There is a growing interest in utilizing single-voxel $$$^1$$$H MR spectroscopy (MRS) for probing the triglyceride fatty acid composition by means of the number of double bounds (ndb) and number of methylene interrupted double bounds (nmidb) per triglyceride as well as the mean fatty acid carbon chain length (CL). The present study investigates the in vitro measurement agreement of fatty acid composition parameters between single-voxel multi-TE and short-TR multi-TI multi-TE (SHORTIE) STEAM spectroscopy and the gold standard gas chromatography-mass spectrometry (GC-MS) in human subcutaneous and visceral adipose tissue samples.

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