Abstract #2586

Relaxometry and magnetisation transfer to quantify the small bowel wall in healthy volunteers

Ali Saleh Alyami^1,2,3, Hannah Grace Williams², Konstantinos Argyriou⁴, Penny Gowland^2,4, Gordon W. Moran^1,4, and Caroline Hoad ^2,4

¹Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³Faculty of Applied Medical Sciences, Diagnostic Radiology, Jazan University, Jazan, Saudi Arabia, ⁴NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust and University of Nottingham, University of Nottingham, Nottingham, United Kingdom

Quantitative MRI datasets based on relaxometry and Magnetisation Transfer (MT) sequences could be used as potential biomarkers of disease activity in Inflammatory Bowel Disease. The aim of the study was to measure the repeatability of T2, T1 and MT small bowel measurements following bowel preparation and administration of an anti-spasmodic agent. Inter-observer variations in these measurements were also assessed. The quantitative MRI methods examined showed excellent repeatability for T2 and good repeatability for T1 parameters for both repeatability between visits and reproducibility of results between observers from data of a small group of healthy subjects.

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