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Abstract #2586

Relaxometry and magnetisation transfer to quantify the small bowel wall in healthy volunteers

Ali Saleh Alyami1,2,3, Hannah Grace Williams2, Konstantinos Argyriou4, Penny Gowland2,4, Gordon W. Moran1,4, and Caroline Hoad 2,4
1Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3Faculty of Applied Medical Sciences, Diagnostic Radiology, Jazan University, Jazan, Saudi Arabia, 4NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust and University of Nottingham, University of Nottingham, Nottingham, United Kingdom

Quantitative MRI datasets based on relaxometry and Magnetisation Transfer (MT) sequences could be used as potential biomarkers of disease activity in Inflammatory Bowel Disease. The aim of the study was to measure the repeatability of T2, T1 and MT small bowel measurements following bowel preparation and administration of an anti-spasmodic agent. Inter-observer variations in these measurements were also assessed. The quantitative MRI methods examined showed excellent repeatability for T2 and good repeatability for T1 parameters for both repeatability between visits and reproducibility of results between observers from data of a small group of healthy subjects.

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